CryoEM structure of MxB reveals a novel oligomerization interface critical for HIV restriction

Human dynamin–like, interferon-induced myxovirus resistance 2 (Mx2 or MxB) is a potent HIV-1 inhibitor. Antiviral activity requires both the amino-terminal region of MxB and protein oligomerization, each of which has eluded structural determination due to difficulties in protein preparation. We repo...

Descripción completa

Detalles Bibliográficos
Autores principales: Alvarez, Frances J. D., He, Shaoda, Perilla, Juan R., Jang, Sooin, Schulten, Klaus, Engelman, Alan N., Scheres, Sjors H. W., Zhang, Peijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600524/
https://www.ncbi.nlm.nih.gov/pubmed/28929138
http://dx.doi.org/10.1126/sciadv.1701264

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600524/
https://www.ncbi.nlm.nih.gov/pubmed/28929138
http://dx.doi.org/10.1126/sciadv.1701264

Ejemplares similares