Discovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma cruzi

[Image: see text] Chagas’ disease, caused by the protozoan parasite Trypanosoma cruzi, is the most common cause of cardiac-related deaths in endemic regions of Latin America. There is an urgent need for new safer treatments because current standard therapeutic options, benznidazole and nifurtimox, h...

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Detalles Bibliográficos
Autores principales: Brand, Stephen, Ko, Eun Jung, Viayna, Elisabet, Thompson, Stephen, Spinks, Daniel, Thomas, Michael, Sandberg, Lars, Francisco, Amanda F., Jayawardhana, Shiromani, Smith, Victoria C., Jansen, Chimed, De Rycker, Manu, Thomas, John, MacLean, Lorna, Osuna-Cabello, Maria, Riley, Jennifer, Scullion, Paul, Stojanovski, Laste, Simeons, Frederick R. C., Epemolu, Ola, Shishikura, Yoko, Crouch, Sabrinia D., Bakshi, Tania S., Nixon, Christopher J., Reid, Iain H., Hill, Alan P., Underwood, Tim Z., Hindley, Sean J., Robinson, Sharon A., Kelly, John M., Fiandor, Jose M., Wyatt, Paul G., Marco, Maria, Miles, Timothy J., Read, Kevin D., Gilbert, Ian H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601362/
https://www.ncbi.nlm.nih.gov/pubmed/28844141
http://dx.doi.org/10.1021/acs.jmedchem.7b00463

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601362/
https://www.ncbi.nlm.nih.gov/pubmed/28844141
http://dx.doi.org/10.1021/acs.jmedchem.7b00463

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