Understanding the Effect of Statins and Patient Adherence in Atherosclerosis via a Quantitative Systems Pharmacology Model Using a Novel, Hybrid, and Multi-Scale Approach

Background and Objective: Statins are one of the most prescribed drugs to treat atherosclerosis. They inhibit the hepatic HMG-CoA reductase, causing a reduction of circulating cholesterol and LDL levels. Statins have had undeniable success; however, the benefits of statin therapy crystallize only if...

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Detalles Bibliográficos
Autores principales: Pichardo-Almarza, Cesar, Diaz-Zuccarini, Vanessa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601395/
https://www.ncbi.nlm.nih.gov/pubmed/28955237
http://dx.doi.org/10.3389/fphar.2017.00635

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601395/
https://www.ncbi.nlm.nih.gov/pubmed/28955237
http://dx.doi.org/10.3389/fphar.2017.00635

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