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The mechano-sensing role of the unique SH3 insertion in plakin domains revealed by Molecular Dynamics simulations
The plakin family of proteins, important actors in cross-linking force-bearing structures in the cell, contain a curious SH3 domain insertion in their chain of spectrin repeats (SRs). While SH3 domains are known to mediate protein-protein interactions, here, its canonical binding site is autoinhibit...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601466/ https://www.ncbi.nlm.nih.gov/pubmed/28916774 http://dx.doi.org/10.1038/s41598-017-11017-2 |