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The mechano-sensing role of the unique SH3 insertion in plakin domains revealed by Molecular Dynamics simulations

The plakin family of proteins, important actors in cross-linking force-bearing structures in the cell, contain a curious SH3 domain insertion in their chain of spectrin repeats (SRs). While SH3 domains are known to mediate protein-protein interactions, here, its canonical binding site is autoinhibit...

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Detalles Bibliográficos
Autores principales: Daday, Csaba, Kolšek, Katra, Gräter, Frauke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601466/
https://www.ncbi.nlm.nih.gov/pubmed/28916774
http://dx.doi.org/10.1038/s41598-017-11017-2