Radiation damage at the active site of human alanine:glyoxylate aminotransferase reveals that the cofactor position is finely tuned during catalysis

The alanine:glyoxylate aminotransferase (AGT), a hepatocyte-specific pyridoxal-5′-phosphate (PLP) dependent enzyme, transaminates L-alanine and glyoxylate to glycine and pyruvate, thus detoxifying glyoxylate and preventing pathological oxalate precipitation in tissues. In the widely accepted catalyt...

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Detalles Bibliográficos
Autores principales: Giardina, Giorgio, Paiardini, Alessandro, Montioli, Riccardo, Cellini, Barbara, Voltattorni, Carla Borri, Cutruzzolà, Francesca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601474/
https://www.ncbi.nlm.nih.gov/pubmed/28916765
http://dx.doi.org/10.1038/s41598-017-11948-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601474/
https://www.ncbi.nlm.nih.gov/pubmed/28916765
http://dx.doi.org/10.1038/s41598-017-11948-w

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