Identification of 4-phenylquinolin-2(1H)-one as a specific allosteric inhibitor of Akt

Akt plays a major role in tumorigenesis and the development of specific Akt inhibitors as effective cancer therapeutics has been challenging. Here, we report the identification of a highly specific allosteric inhibitor of Akt through a FRET-based high-throughput screening, and characterization of it...

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Detalles Bibliográficos
Autores principales: Huang, Bill X., Newcomer, Kenny, Kevala, Karl, Barnaeva, Elena, Zheng, Wei, Hu, Xin, Patnaik, Samarjit, Southall, Noel, Marugan, Juan, Ferrer, Marc, Kim, Hee-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601486/
https://www.ncbi.nlm.nih.gov/pubmed/28916818
http://dx.doi.org/10.1038/s41598-017-11870-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601486/
https://www.ncbi.nlm.nih.gov/pubmed/28916818
http://dx.doi.org/10.1038/s41598-017-11870-1

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