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Identification of 4-phenylquinolin-2(1H)-one as a specific allosteric inhibitor of Akt
Akt plays a major role in tumorigenesis and the development of specific Akt inhibitors as effective cancer therapeutics has been challenging. Here, we report the identification of a highly specific allosteric inhibitor of Akt through a FRET-based high-throughput screening, and characterization of it...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601486/ https://www.ncbi.nlm.nih.gov/pubmed/28916818 http://dx.doi.org/10.1038/s41598-017-11870-1 |