p53-independent p21 induction by MELK inhibition

MELK play critical roles in human carcinogenesis through activation of cell proliferation, inhibition of apoptosis and maintenance of stemness. Therefore, MELK is a promising therapeutic target for a wide range of cancers. Although p21 is a well-known p53-downstream gene, we found that treatment wit...

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Detalles Bibliográficos
Autores principales: Matsuda, Tatsuo, Kato, Taigo, Kiyotani, Kazuma, Tarhan, Yunus Emre, Saloura, Vassiliki, Chung, Suyoun, Ueda, Koji, Nakamura, Yusuke, Park, Jae-Hyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601624/
https://www.ncbi.nlm.nih.gov/pubmed/28938528
http://dx.doi.org/10.18632/oncotarget.18488

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601624/
https://www.ncbi.nlm.nih.gov/pubmed/28938528
http://dx.doi.org/10.18632/oncotarget.18488

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