CD3xPDL1 bi-specific T cell engager (BiTE) simultaneously activates T cells and NKT cells, kills PDL1(+) tumor cells, and extends the survival of tumor-bearing humanized mice

Bi-specific T cell engagers (BiTEs) activate T cells through CD3 and target activated T cells to tumor-expressed antigens. BiTEs have shown therapeutic efficacy in patients with liquid tumors; however, they do not benefit all patients. Anti-tumor immunity is limited by Programmed Death 1 (PD1) pathw...

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Detalles Bibliográficos
Autores principales: Horn, Lucas A., Ciavattone, Nicholas G., Atkinson, Ryan, Woldergerima, Netsanet, Wolf, Julia, Clements, Virginia K., Sinha, Pratima, Poudel, Munanchu, Ostrand-Rosenberg, Suzanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601626/
https://www.ncbi.nlm.nih.gov/pubmed/28938530
http://dx.doi.org/10.18632/oncotarget.19865

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601626/
https://www.ncbi.nlm.nih.gov/pubmed/28938530
http://dx.doi.org/10.18632/oncotarget.19865

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