The dual PI3K/mTOR inhibitor GSK2126458 is effective for treating solid renal tumours in Tsc2(+/-) mice through suppression of cell proliferation and induction of apoptosis

Tuberous sclerosis (TSC) is an inherited tumour syndrome caused by mutations in TSC1 or TSC2 that lead to aberrant activation of mTOR. Tumour responses in TSC patients to rapamycin, an allosteric inhibitor of mTOR, or its analogs are partial and reversible probably due to feedback activation of Akt....

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Detalles Bibliográficos
Autores principales: Narov, Kalin, Yang, Jian, Samsel, Paulina, Jones, Ashley, Sampson, Julian R, Shen, Ming Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601670/
https://www.ncbi.nlm.nih.gov/pubmed/28938574
http://dx.doi.org/10.18632/oncotarget.17215

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601670/
https://www.ncbi.nlm.nih.gov/pubmed/28938574
http://dx.doi.org/10.18632/oncotarget.17215

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