Mutation-profile-based methods for understanding selection forces in cancer somatic mutations: a comparative analysis

Human genes exhibit different effects on fitness in cancer and normal cells. Here, we present an evolutionary approach to measure the selection pressure on human genes, using the well-known ratio of the nonsynonymous to synonymous substitution rate in both cancer genomes (C(N)/C(S)) and normal popul...

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Detalles Bibliográficos
Autores principales: Zhou, Zhan, Zou, Yangyun, Liu, Gangbiao, Zhou, Jingqi, Wu, Jingcheng, Zhao, Shimin, Su, Zhixi, Gu, Xun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601697/
https://www.ncbi.nlm.nih.gov/pubmed/28938601
http://dx.doi.org/10.18632/oncotarget.19371

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601697/
https://www.ncbi.nlm.nih.gov/pubmed/28938601
http://dx.doi.org/10.18632/oncotarget.19371

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