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Mutation-profile-based methods for understanding selection forces in cancer somatic mutations: a comparative analysis
Human genes exhibit different effects on fitness in cancer and normal cells. Here, we present an evolutionary approach to measure the selection pressure on human genes, using the well-known ratio of the nonsynonymous to synonymous substitution rate in both cancer genomes (C(N)/C(S)) and normal popul...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Impact Journals LLC
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601697/ https://www.ncbi.nlm.nih.gov/pubmed/28938601 http://dx.doi.org/10.18632/oncotarget.19371 |