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Design of Multivalent Inhibitors for Preventing Cellular Uptake

Cellular entry, the first crucial step of viral infection, can be inhibited by molecules adsorbed on the virus surface. However, apart from using stronger affinity, little is known about the properties of such inhibitors that could increase their effectiveness. Our simulations showed that multivalen...

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Detalles Bibliográficos
Autores principales: Schubertová, Veronika, Martinez-Veracoechea, Francisco J., Vácha, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601900/
https://www.ncbi.nlm.nih.gov/pubmed/28916832
http://dx.doi.org/10.1038/s41598-017-11735-7