Rapid and reversible epigenome editing by endogenous chromatin regulators

Understanding the causal link between epigenetic marks and gene regulation remains a central question in chromatin biology. To edit the epigenome we developed the FIRE-Cas9 system for rapid and reversible recruitment of endogenous chromatin regulators to specific genomic loci. We enhanced the dCas9–...

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Detalles Bibliográficos
Autores principales: Braun, Simon M. G., Kirkland, Jacob G., Chory, Emma J., Husmann, Dylan, Calarco, Joseph P., Crabtree, Gerald R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601922/
https://www.ncbi.nlm.nih.gov/pubmed/28916764
http://dx.doi.org/10.1038/s41467-017-00644-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601922/
https://www.ncbi.nlm.nih.gov/pubmed/28916764
http://dx.doi.org/10.1038/s41467-017-00644-y

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