Checkpoint blockade immunotherapy reshapes the high-dimensional phenotypic heterogeneity of murine intratumoural neoantigen-specific CD8(+) T cells

The analysis of neoantigen-specific CD8(+) T cells in tumour-bearing individuals is challenging due to the small pool of tumour antigen-specific T cells. Here we show that mass cytometry with multiplex combinatorial tetramer staining can identify and characterize neoantigen-specific CD8(+) T cells i...

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Detalles Bibliográficos
Autores principales: Fehlings, M., Simoni, Y., Penny, H. L., Becht, E., Loh, C. Y., Gubin, M. M., Ward, J. P., Wong, S. C., Schreiber, R. D., Newell, E. W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601925/
https://www.ncbi.nlm.nih.gov/pubmed/28916749
http://dx.doi.org/10.1038/s41467-017-00627-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601925/
https://www.ncbi.nlm.nih.gov/pubmed/28916749
http://dx.doi.org/10.1038/s41467-017-00627-z

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