The melanocortin signaling cAMP axis accelerates repair and reduces mutagenesis of platinum-induced DNA damage

Using primary melanocytes and HEK293 cells, we found that cAMP signaling accelerates repair of bi- and mono-functional platinum-induced DNA damage. Elevating cAMP signaling either by the agonistic MC1R ligand melanocyte stimulating hormone (MSH) or by pharmacologic cAMP induction by forskolin enhanc...

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Detalles Bibliográficos
Autores principales: Jarrett, Stuart G., Carter, Katharine M., Shelton, Brent J., D’Orazio, John A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601928/
https://www.ncbi.nlm.nih.gov/pubmed/28916831
http://dx.doi.org/10.1038/s41598-017-12056-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601928/
https://www.ncbi.nlm.nih.gov/pubmed/28916831
http://dx.doi.org/10.1038/s41598-017-12056-5

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