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The melanocortin signaling cAMP axis accelerates repair and reduces mutagenesis of platinum-induced DNA damage
Using primary melanocytes and HEK293 cells, we found that cAMP signaling accelerates repair of bi- and mono-functional platinum-induced DNA damage. Elevating cAMP signaling either by the agonistic MC1R ligand melanocyte stimulating hormone (MSH) or by pharmacologic cAMP induction by forskolin enhanc...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601928/ https://www.ncbi.nlm.nih.gov/pubmed/28916831 http://dx.doi.org/10.1038/s41598-017-12056-5 |