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CDK9 and SPT5 proteins are specifically required for expression of herpes simplex virus 1 replication-dependent late genes
DNA replication greatly enhances expression of the herpes simplex virus 1 (HSV-1) γ2 late genes by still unknown mechanisms. Here, we demonstrate that 5,6-dichloro-1-β-d-ribofuranosylbenzimidazole (DRB), an inhibitor of CDK9, suppresses expression of γ2 late genes with an IC(50) of 5 μm, which is at...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5602406/ https://www.ncbi.nlm.nih.gov/pubmed/28743741 http://dx.doi.org/10.1074/jbc.M117.806000 |