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CDK9 and SPT5 proteins are specifically required for expression of herpes simplex virus 1 replication-dependent late genes

DNA replication greatly enhances expression of the herpes simplex virus 1 (HSV-1) γ2 late genes by still unknown mechanisms. Here, we demonstrate that 5,6-dichloro-1-β-d-ribofuranosylbenzimidazole (DRB), an inhibitor of CDK9, suppresses expression of γ2 late genes with an IC(50) of 5 μm, which is at...

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Detalles Bibliográficos
Autores principales:	Zhao, Zhiyuan, Tang, Ka-Wei, Muylaert, Isabella, Samuelsson, Tore, Elias, Per
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2017
Materias:	Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5602406/ https://www.ncbi.nlm.nih.gov/pubmed/28743741 http://dx.doi.org/10.1074/jbc.M117.806000

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