Profiling the Mismatch Tolerance of Argonaute 2 through Deep Sequencing of Sliced Polymorphic Viral RNAs

Low allelic and clonal variability among endogenous RNAi targets has focused mismatch tolerance studies to RNAi-active guide strands. However, the inherent genomic instability of RNA viruses such as hepatitis C virus (HCV) gives rise to quasi-species mutants within discrete clones: this facilitates...

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Detalles Bibliográficos
Autores principales: Theotokis, Pantazis I., Usher, Louise, Kortschak, Christopher K., Schwalbe, Ed, Moschos, Sterghios A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5602524/
https://www.ncbi.nlm.nih.gov/pubmed/29246301
http://dx.doi.org/10.1016/j.omtn.2017.08.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5602524/
https://www.ncbi.nlm.nih.gov/pubmed/29246301
http://dx.doi.org/10.1016/j.omtn.2017.08.010

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