Assessment of the Drug Interaction Potential of Unconjugated and GalNAc(3)-Conjugated 2′-MOE-ASOs

Antisense oligonucleotides are metabolized by nucleases and drug interactions with small drug molecules at either the cytochrome P450 (CYP) enzyme or transporter levels have not been observed to date. Herein, a comprehensive in vitro assessment of the drug-drug interaction (DDI) potential was carrie...

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Detalles Bibliográficos
Autores principales: Shemesh, Colby S., Yu, Rosie Z., Warren, Mark S., Liu, Michael, Jahic, Mirza, Nichols, Brandon, Post, Noah, Lin, Song, Norris, Daniel A., Hurh, Eunju, Huang, Jane, Watanabe, Tanya, Henry, Scott P., Wang, Yanfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5602538/
https://www.ncbi.nlm.nih.gov/pubmed/29246313
http://dx.doi.org/10.1016/j.omtn.2017.08.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5602538/
https://www.ncbi.nlm.nih.gov/pubmed/29246313
http://dx.doi.org/10.1016/j.omtn.2017.08.012

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