New carboxamide derivatives bearing benzenesulphonamide as a selective COX-II inhibitor: Design, synthesis and structure-activity relationship

Sixteen new carboxamide derivatives bearing substituted benzenesulphonamide moiety (7a-p) were synthesized by boric acid mediated amidation of appropriate benzenesulphonamide with 2-amino-4-picoline and tested for anti-inflammatory activity. One compound 7c showed more potent anti-inflammatory activ...

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Detalles Bibliográficos
Autores principales: Ugwu, David Izuchukwu, Okoro, Uchechukwu Chris, Ahmad, Hilal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5602572/
https://www.ncbi.nlm.nih.gov/pubmed/28922386
http://dx.doi.org/10.1371/journal.pone.0183807

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5602572/
https://www.ncbi.nlm.nih.gov/pubmed/28922386
http://dx.doi.org/10.1371/journal.pone.0183807

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