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The Warburg effect as an adaptation of cancer cells to rapid fluctuations in energy demand

To maintain optimal fitness, a cell must balance the risk of inadequate energy reserve for response to a potentially fatal perturbation against the long-term cost of maintaining high concentrations of ATP to meet occasional spikes in demand. Here we apply a game theoretic approach to address the dyn...

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Detalles Bibliográficos
Autores principales: Epstein, Tamir, Gatenby, Robert A., Brown, Joel S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5602667/
https://www.ncbi.nlm.nih.gov/pubmed/28922380
http://dx.doi.org/10.1371/journal.pone.0185085