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The Warburg effect as an adaptation of cancer cells to rapid fluctuations in energy demand
To maintain optimal fitness, a cell must balance the risk of inadequate energy reserve for response to a potentially fatal perturbation against the long-term cost of maintaining high concentrations of ATP to meet occasional spikes in demand. Here we apply a game theoretic approach to address the dyn...
Autores principales: | Epstein, Tamir, Gatenby, Robert A., Brown, Joel S. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5602667/ https://www.ncbi.nlm.nih.gov/pubmed/28922380 http://dx.doi.org/10.1371/journal.pone.0185085 |
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