Role of the P2 residue of human alpha 1-antitrypsin in determining target protease specificity

Alpha 1-antitrypsin (A1AT) is a serine protease inhibitor that mainly inhibits neutrophil elastase in the lungs. A variant of A1AT at the P1 position with methionine 358 to arginine (A1AT-Pittsburgh) is a rapid inhibitor of thrombin with greatly diminished anti-elastase activity. The P2 residue (pos...

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Detalles Bibliográficos
Autores principales: Chung, Hye-Shin, Kim, Ji-Sun, Lee, Sang Mee, Park, Soon Jae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5602671/
https://www.ncbi.nlm.nih.gov/pubmed/28922398
http://dx.doi.org/10.1371/journal.pone.0185074

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5602671/
https://www.ncbi.nlm.nih.gov/pubmed/28922398
http://dx.doi.org/10.1371/journal.pone.0185074

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