Cargando…

Epigenetic clocks for gestational age: statistical and study design considerations

In this letter to the editor, we highlight some concerns with a recently published method to estimate gestational age at delivery from DNA methylation data. We conduct novel analyses to highlight the implications of different choices in study design and statistical methods for the prediction of phen...

Descripción completa

Detalles Bibliográficos
Autores principales: Simpkin, Andrew J., Suderman, Matthew, Howe, Laura D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5602851/
https://www.ncbi.nlm.nih.gov/pubmed/28932320
http://dx.doi.org/10.1186/s13148-017-0402-y
_version_ 1783264634026852352
author Simpkin, Andrew J.
Suderman, Matthew
Howe, Laura D.
author_facet Simpkin, Andrew J.
Suderman, Matthew
Howe, Laura D.
author_sort Simpkin, Andrew J.
collection PubMed
description In this letter to the editor, we highlight some concerns with a recently published method to estimate gestational age at delivery from DNA methylation data. We conduct novel analyses to highlight the implications of different choices in study design and statistical methods for the prediction of phenotypes from methylation data.
format Online
Article
Text
id pubmed-5602851
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-56028512017-09-20 Epigenetic clocks for gestational age: statistical and study design considerations Simpkin, Andrew J. Suderman, Matthew Howe, Laura D. Clin Epigenetics Letter to the Editor In this letter to the editor, we highlight some concerns with a recently published method to estimate gestational age at delivery from DNA methylation data. We conduct novel analyses to highlight the implications of different choices in study design and statistical methods for the prediction of phenotypes from methylation data. BioMed Central 2017-09-15 /pmc/articles/PMC5602851/ /pubmed/28932320 http://dx.doi.org/10.1186/s13148-017-0402-y Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Letter to the Editor
Simpkin, Andrew J.
Suderman, Matthew
Howe, Laura D.
Epigenetic clocks for gestational age: statistical and study design considerations
title Epigenetic clocks for gestational age: statistical and study design considerations
title_full Epigenetic clocks for gestational age: statistical and study design considerations
title_fullStr Epigenetic clocks for gestational age: statistical and study design considerations
title_full_unstemmed Epigenetic clocks for gestational age: statistical and study design considerations
title_short Epigenetic clocks for gestational age: statistical and study design considerations
title_sort epigenetic clocks for gestational age: statistical and study design considerations
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5602851/
https://www.ncbi.nlm.nih.gov/pubmed/28932320
http://dx.doi.org/10.1186/s13148-017-0402-y
work_keys_str_mv AT simpkinandrewj epigeneticclocksforgestationalagestatisticalandstudydesignconsiderations
AT sudermanmatthew epigeneticclocksforgestationalagestatisticalandstudydesignconsiderations
AT howelaurad epigeneticclocksforgestationalagestatisticalandstudydesignconsiderations