Ornithine uptake and the modulation of drug sensitivity in Trypanosoma brucei

Trypanosoma brucei, protozoan parasites that cause human African trypanosomiasis (HAT), depend on ornithine uptake and metabolism by ornithine decarboxylase (ODC) for survival. Indeed, ODC is the target of the WHO “essential medicine” eflornithine, which is antagonistic to another anti-HAT drug, sur...

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Detalles Bibliográficos
Autores principales: Macedo, Juan P., Currier, Rachel B., Wirdnam, Corina, Horn, David, Alsford, Sam, Rentsch, Doris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Federation of American Societies for Experimental Biology 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5602898/
https://www.ncbi.nlm.nih.gov/pubmed/28679527
http://dx.doi.org/10.1096/fj.201700311R

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5602898/
https://www.ncbi.nlm.nih.gov/pubmed/28679527
http://dx.doi.org/10.1096/fj.201700311R

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