IL-4 Induces Metallothionein 3- and SLC30A4-Dependent Increase in Intracellular Zn(2+) that Promotes Pathogen Persistence in Macrophages

Alternative activation of macrophages promotes wound healing but weakens antimicrobial defenses against intracellular pathogens. The mechanisms that suppress macrophage function to create a favorable environment for pathogen growth remain elusive. We show that interleukin (IL)-4 triggers a metalloth...

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Detalles Bibliográficos
Autores principales: Vignesh, Kavitha Subramanian, Landero Figueroa, Julio A., Porollo, Aleksey, Divanovic, Senad, Caruso, Joseph A., Deepe, George S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5603080/
https://www.ncbi.nlm.nih.gov/pubmed/27653687
http://dx.doi.org/10.1016/j.celrep.2016.08.057

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5603080/
https://www.ncbi.nlm.nih.gov/pubmed/27653687
http://dx.doi.org/10.1016/j.celrep.2016.08.057

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