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The tyrosine phosphatase PTPN13/FAP-1 links calpain-2, TBI and tau tyrosine phosphorylation

Traumatic brain injury (TBI) increases the risk of Alzheimer’s disease (AD). Calpain activation and tau hyperphosphorylation have been implicated in both TBI and AD. However, the link between calpain and tau phosphorylation has not been fully identified. We recently discovered that the two major cal...

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Detalles Bibliográficos
Autores principales: Wang, Yubin, Hall, Randy A., Lee, Moses, Kamgar-parsi, Andysheh, Bi, Xiaoning, Baudry, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5603515/
https://www.ncbi.nlm.nih.gov/pubmed/28924170
http://dx.doi.org/10.1038/s41598-017-12236-3