Mitophagy Failure in Fibroblasts and iPSC-Derived Neurons of Alzheimer’s Disease-Associated Presenilin 1 Mutation

Familial Alzheimer’s disease (FAD) is clearly related with the accumulation of amyloid-beta (Aβ) and its deleterious effect on mitochondrial function is well established. Anomalies in autophagy have also been described in these patients. In the present work, functional analyses have been performed t...

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Detalles Bibliográficos
Autores principales: Martín-Maestro, Patricia, Gargini, Ricardo, A. Sproul, Andrew, García, Esther, Antón, Luis C., Noggle, Scott, Arancio, Ottavio, Avila, Jesús, García-Escudero, Vega
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5603661/
https://www.ncbi.nlm.nih.gov/pubmed/28959184
http://dx.doi.org/10.3389/fnmol.2017.00291

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5603661/
https://www.ncbi.nlm.nih.gov/pubmed/28959184
http://dx.doi.org/10.3389/fnmol.2017.00291

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