Bmi1 limits dilated cardiomyopathy and heart failure by inhibiting cardiac senescence

Dilated cardiomyopathy (DCM) is the most frequent cause of heart failure and the leading indication for heart transplantation. Here we show that epigenetic regulator and central transcriptional instructor in adult stem cells, Bmi1, protects against DCM by repressing cardiac senescence. Cardiac-speci...

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Detalles Bibliográficos
Autores principales: Gonzalez-Valdes, I., Hidalgo, I., Bujarrabal, A., Lara-Pezzi, E., Padron-Barthe, L., Garcia-Pavia, P., Gómez-del Arco, Pablo, Redondo, J.M., Ruiz-Cabello, J.M., Jimenez-Borreguero, L.J., Enriquez, J.A., de la Pompa, J.L., Hidalgo, A., Gonzalez, S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5603726/
https://www.ncbi.nlm.nih.gov/pubmed/25751743
http://dx.doi.org/10.1038/ncomms7473

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5603726/
https://www.ncbi.nlm.nih.gov/pubmed/25751743
http://dx.doi.org/10.1038/ncomms7473

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