Antineoplastic effects of histone deacetylase inhibitors in neuroendocrine cancer cells are mediated through transcriptional regulation of Notch1 by activator protein 1

Notch signaling is minimally active in neuroendocrine (NE) cancer cells. While histone deacetylase inhibitors (HDACi) suppress NE cancer growth by inducing Notch, the molecular mechanism underlying this interplay has not yet been defined. NE cancer cell lines BON, H727, and MZ‐CRC‐1 were treated wit...

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Detalles Bibliográficos
Autores principales: Jang, Samuel, Jin, Haining, Roy, Madhuchhanda, Ma, Alice L., Gong, Shaoqin, Jaskula‐Sztul, Renata, Chen, Herbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5603840/
https://www.ncbi.nlm.nih.gov/pubmed/28776955
http://dx.doi.org/10.1002/cam4.1151

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5603840/
https://www.ncbi.nlm.nih.gov/pubmed/28776955
http://dx.doi.org/10.1002/cam4.1151

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