A complex stereochemical relay approach to the antimalarial alkaloid ocimicide A(1). Evidence for a structural revision

Ocimicide A(1) (1) and the semisynthetic derivative ocimicide A(2) (2) are highly potent antimalarial agents efficacious against chloroquine-sensitive and -resistant Plasmodium falciparum strains with IC(50) values in the nanomolar and picomolar range, respectively. Members of this family have demon...

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Detalles Bibliográficos
Autores principales: Nikolayevskiy, Herman, Moe Tun, Maung Kyaw, Rablen, Paul R., Ben Mamoun, Choukri, Herzon, Seth B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5603897/
https://www.ncbi.nlm.nih.gov/pubmed/28959410
http://dx.doi.org/10.1039/c7sc01127j

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5603897/
https://www.ncbi.nlm.nih.gov/pubmed/28959410
http://dx.doi.org/10.1039/c7sc01127j

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