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Single copy-sensitive electrochemical assay for circulating methylated DNA in clinical samples with ultrahigh specificity based on a sequential discrimination–amplification strategy

Tumor-related circulating methylated DNA represents only a small fraction of the total DNA in clinical samples (e.g. plasma), challenging the accurate analysis of specific DNA methylation patterns. Yet conventional assays based on the real-time quantitative methylation-specific PCR (qMSP) are genera...

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Detalles Bibliográficos
Autores principales:	Wang, Xuyao, Chen, Feng, Zhang, Dexin, Zhao, Yue, Wei, Jing, Wang, Lihua, Song, Shiping, Fan, Chunhai, Zhao, Yongxi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2017
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5603958/ https://www.ncbi.nlm.nih.gov/pubmed/28959399 http://dx.doi.org/10.1039/c7sc01035d

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