DNA epigenome editing using CRISPR-Cas SunTag-directed DNMT3A

BACKGROUND: DNA methylation has widespread effects on gene expression during development. However, our ability to assign specific function to regions of DNA methylation is limited by the poor correlation between global patterns of DNA methylation and gene expression. RESULTS: Here, we utilize nuclea...

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Detalles Bibliográficos
Autores principales: Huang, Yung-Hsin, Su, Jianzhong, Lei, Yong, Brunetti, Lorenzo, Gundry, Michael C., Zhang, Xiaotian, Jeong, Mira, Li, Wei, Goodell, Margaret A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604343/
https://www.ncbi.nlm.nih.gov/pubmed/28923089
http://dx.doi.org/10.1186/s13059-017-1306-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604343/
https://www.ncbi.nlm.nih.gov/pubmed/28923089
http://dx.doi.org/10.1186/s13059-017-1306-z

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