Dihydroorotate dehydrogenase Inhibitors Target c-Myc and Arrest Melanoma, Myeloma and Lymphoma cells at S-phase

Dihydroorotate dehydrogenase (DHODH) is a rate-limiting enzyme in the de novo biosynthesis pathway of pyrimidines. Inhibition of this enzyme impedes cancer cell proliferation but the exact mechanisms of action of these inhibitors in cancer cells are poorly understood. In this study, we showed that c...

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Detalles Bibliográficos
Autores principales: Dorasamy, Mathura Subangari, Choudhary, Bhavesh, Nellore, Kavitha, Subramanya, Hosahalli, Wong, Pooi-Fong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604460/
https://www.ncbi.nlm.nih.gov/pubmed/28928900
http://dx.doi.org/10.7150/jca.14835

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604460/
https://www.ncbi.nlm.nih.gov/pubmed/28928900
http://dx.doi.org/10.7150/jca.14835

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