Pharmacokinetic and safety evaluation of MB12066, an NQO1 substrate

OBJECTIVE: This study evaluated the pharmacokinetics (PKs) and safety of a newly developed β-lapachone (MB12066) tablet, a natural NAD(P)H:quinone oxidoreductase 1 (NQO1) substrate, in healthy male volunteers. METHODS: In a randomized, double-blind, multiple-dose, two-treatment study, 100 mg MB12066...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Hae Won, Seong, Sook Jin, Ohk, Boram, Kang, Woo Youl, Gwon, Mi-Ri, Kim, Bo Kyung, Kim, Hyun-Ju, Yoon, Young-Ran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604554/
https://www.ncbi.nlm.nih.gov/pubmed/29066863
http://dx.doi.org/10.2147/DDDT.S142339

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604554/
https://www.ncbi.nlm.nih.gov/pubmed/29066863
http://dx.doi.org/10.2147/DDDT.S142339

Ejemplares similares