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Pharmacokinetic and safety evaluation of MB12066, an NQO1 substrate

OBJECTIVE: This study evaluated the pharmacokinetics (PKs) and safety of a newly developed β-lapachone (MB12066) tablet, a natural NAD(P)H:quinone oxidoreductase 1 (NQO1) substrate, in healthy male volunteers. METHODS: In a randomized, double-blind, multiple-dose, two-treatment study, 100 mg MB12066...

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Detalles Bibliográficos
Autores principales:	Lee, Hae Won, Seong, Sook Jin, Ohk, Boram, Kang, Woo Youl, Gwon, Mi-Ri, Kim, Bo Kyung, Kim, Hyun-Ju, Yoon, Young-Ran
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2017
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604554/ https://www.ncbi.nlm.nih.gov/pubmed/29066863 http://dx.doi.org/10.2147/DDDT.S142339

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