Methotrexate and low-dose prednisolone downregulate osteoclast function by decreasing receptor activator of nuclear factor-κβ expression in monocytes from patients with early rheumatoid arthritis

OBJECTIVE: Rheumatoid arthritis (RA) is a systemic, immune-mediated inflammatory disease that ultimately leads to bone erosions and joint destruction. Methotrexate (MTX) slows bone damage but the mechanism by which it acts is still unknown. In this study, we aimed to assess the effect of MTX and low...

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Detalles Bibliográficos
Autores principales: Perpétuo, Inês Pedro, Caetano-Lopes, Joana, Rodrigues, Ana Maria, Campanilho-Marques, Raquel, Ponte, Cristina, Canhão, Helena, Ainola, Mari, Fonseca, João Eurico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RMD Open 2017
Materias:
Rheumatoid Arthritis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604603/
https://www.ncbi.nlm.nih.gov/pubmed/28955481
http://dx.doi.org/10.1136/rmdopen-2016-000365

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604603/
https://www.ncbi.nlm.nih.gov/pubmed/28955481
http://dx.doi.org/10.1136/rmdopen-2016-000365

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