Safety, pharmacokinetics and pharmacodynamics of AMG 811, an anti-interferon-γ monoclonal antibody, in SLE subjects without or with lupus nephritis

OBJECTIVE: To evaluate safety, pharmacokinetics and pharmacodynamics of anti-interferon (IFN)-γ monoclonal antibody AMG 811 in subjects with SLE without or with lupus nephritis (LN). METHODS: In this phase Ib, randomised, multiple-dose escalation study (NCT00818948), subjects without LN were randomi...

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Detalles Bibliográficos
Autores principales: Boedigheimer, Michael J, Martin, David A, Amoura, Zahir, Sánchez-Guerrero, Jorge, Romero-Diaz, Juanita, Kivitz, Alan, Aranow, Cynthia, Chan, Tak Mao, Chong, Yip Boon, Chiu, Kit, Wang, Christine, Sohn, Winnie, Arnold, Gregory E, Damore, Michael A, Welcher, Andrew A, Sullivan, Barbara A, Kotzin, Brian L, Chung, James B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2017
Materias:
Lupus Nephritis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604705/
https://www.ncbi.nlm.nih.gov/pubmed/29018537
http://dx.doi.org/10.1136/lupus-2017-000226

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604705/
https://www.ncbi.nlm.nih.gov/pubmed/29018537
http://dx.doi.org/10.1136/lupus-2017-000226

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