Fluoxetine ameliorates cartilage degradation in osteoarthritis by inhibiting Wnt/β-catenin signaling

Abnormal activation of the Wnt/β-catenin signaling is implicated in the osteoarthritis (OA) pathology. We searched for a pre-approved drug that suppresses abnormally activated Wnt/β-catenin signaling and has a potency to reduce joint pathology in OA. We introduced the TOPFlash reporter plasmid into...

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Detalles Bibliográficos
Autores principales: Miyamoto, Kentaro, Ohkawara, Bisei, Ito, Mikako, Masuda, Akio, Hirakawa, Akihiro, Sakai, Tadahiro, Hiraiwa, Hideki, Hamada, Takashi, Ishiguro, Naoki, Ohno, Kinji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604944/
https://www.ncbi.nlm.nih.gov/pubmed/28926590
http://dx.doi.org/10.1371/journal.pone.0184388

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604944/
https://www.ncbi.nlm.nih.gov/pubmed/28926590
http://dx.doi.org/10.1371/journal.pone.0184388

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