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Fluoxetine ameliorates cartilage degradation in osteoarthritis by inhibiting Wnt/β-catenin signaling

Abnormal activation of the Wnt/β-catenin signaling is implicated in the osteoarthritis (OA) pathology. We searched for a pre-approved drug that suppresses abnormally activated Wnt/β-catenin signaling and has a potency to reduce joint pathology in OA. We introduced the TOPFlash reporter plasmid into...

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Detalles Bibliográficos
Autores principales:	Miyamoto, Kentaro, Ohkawara, Bisei, Ito, Mikako, Masuda, Akio, Hirakawa, Akihiro, Sakai, Tadahiro, Hiraiwa, Hideki, Hamada, Takashi, Ishiguro, Naoki, Ohno, Kinji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604944/ https://www.ncbi.nlm.nih.gov/pubmed/28926590 http://dx.doi.org/10.1371/journal.pone.0184388

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