A novel class of chemicals that react with abasic sites in DNA and specifically kill B cell cancers

Most B cell cancers overexpress the enzyme activation-induced deaminase at high levels and this enzyme converts cytosines in DNA to uracil. The constitutive expression of this enzyme in these cells greatly increases the uracil content of their genomes. We show here that these genomes also contain hi...

Descripción completa

Detalles Bibliográficos
Autores principales: Wei, Shanqiao, Perera, Madusha L. W., Sakhtemani, Ramin, Bhagwat, Ashok S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605088/
https://www.ncbi.nlm.nih.gov/pubmed/28926604
http://dx.doi.org/10.1371/journal.pone.0185010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605088/
https://www.ncbi.nlm.nih.gov/pubmed/28926604
http://dx.doi.org/10.1371/journal.pone.0185010

Ejemplares similares