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A novel class of chemicals that react with abasic sites in DNA and specifically kill B cell cancers
Most B cell cancers overexpress the enzyme activation-induced deaminase at high levels and this enzyme converts cytosines in DNA to uracil. The constitutive expression of this enzyme in these cells greatly increases the uracil content of their genomes. We show here that these genomes also contain hi...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605088/ https://www.ncbi.nlm.nih.gov/pubmed/28926604 http://dx.doi.org/10.1371/journal.pone.0185010 |