SFPQ•NONO and XLF function separately and together to promote DNA double-strand break repair via canonical nonhomologous end joining

A complex of two related mammalian proteins, SFPQ and NONO, promotes DNA double-strand break repair via the canonical nonhomologous end joining (c-NHEJ) pathway. However, its mechanism of action is not fully understood. Here we describe an improved SFPQ•NONO-dependent in vitro end joining assay. We...

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Detalles Bibliográficos
Autores principales: Jaafar, Lahcen, Li, Zhentian, Li, Shuyi, Dynan, William S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605232/
https://www.ncbi.nlm.nih.gov/pubmed/27924002
http://dx.doi.org/10.1093/nar/gkw1209

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605232/
https://www.ncbi.nlm.nih.gov/pubmed/27924002
http://dx.doi.org/10.1093/nar/gkw1209

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