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Crystal structure of the N-terminal domain of human Timeless and its interaction with Tipin

Human Timeless is involved in replication fork stabilization, S-phase checkpoint activation and establishment of sister chromatid cohesion. In the cell, Timeless forms a constitutive heterodimeric complex with Tipin. Here we present the 1.85 Å crystal structure of a large N-terminal segment of human...

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Detalles Bibliográficos
Autores principales: Holzer, Sandro, Degliesposti, Gianluca, Kilkenny, Mairi L., Maslen, Sarah L., Matak-Vinkovíc, Dijana, Skehel, Mark, Pellegrini, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605233/
https://www.ncbi.nlm.nih.gov/pubmed/28334766
http://dx.doi.org/10.1093/nar/gkx139