Cargando…
Truncated ORF1 proteins can suppress LINE-1 retrotransposition in trans
Long interspersed element 1 (L1) is an autonomous non-LTR retroelement that is active in mammalian genomes. Although retrotranspositionally incompetent and functional L1 loci are present in the same genomes, it remains unknown whether non-functional L1s have any trans effect on mobilization of activ...
Autores principales: | Sokolowski, Mark, Chynces, May, deHaro, Dawn, Christian, Claiborne M., Belancio, Victoria P. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605252/ https://www.ncbi.nlm.nih.gov/pubmed/28431148 http://dx.doi.org/10.1093/nar/gkx211 |
Ejemplares similares
-
Identification of L1 ORF2p sequence important to retrotransposition using Bipartile Alu retrotransposition (BAR)
por: Christian, Claiborne M., et al.
Publicado: (2016) -
Potential for genomic instability associated with retrotranspositionally-incompetent L1 loci
por: Kines, Kristine J., et al.
Publicado: (2014) -
The endonuclease domain of the LINE-1 ORF2 protein can tolerate multiple mutations
por: Kines, Kristine J., et al.
Publicado: (2016) -
Characterization of L1 ORF1p Self-Interaction and Cellular Localization Using a Mammalian Two-Hybrid System
por: Sokolowski, Mark, et al.
Publicado: (2013) -
Development of a monoclonal antibody specific to the endonuclease domain of the human LINE-1 ORF2 protein
por: Sokolowski, Mark, et al.
Publicado: (2014)