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Neutrophil Membrane Cholesterol Content is a Key Factor in Cystic Fibrosis Lung Disease

BACKGROUND: Identification of mechanisms promoting neutrophil trafficking to the lungs of patients with cystic fibrosis (CF) is a challenge for next generation therapeutics. Cholesterol, a structural component of neutrophil plasma membranes influences cell adhesion, a key step in transmigration. The...

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Detalles Bibliográficos
Autores principales: White, Michelle M., Geraghty, Patrick, Hayes, Elaine, Cox, Stephen, Leitch, William, Alfawaz, Bader, Lavelle, Gillian M., McElvaney, Oliver J., Flannery, Ryan, Keenan, Joanne, Meleady, Paula, Henry, Michael, Clynes, Martin, Gunaratnam, Cedric, McElvaney, Noel G., Reeves, Emer P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605378/
https://www.ncbi.nlm.nih.gov/pubmed/28835336
http://dx.doi.org/10.1016/j.ebiom.2017.08.013