The PNPLA3 variant associated with fatty liver disease (I148M) accumulates on lipid droplets by evading ubiquitylation

A sequence variation (I148M) in patatin‐like phospholipase domain‐containing protein 3 (PNPLA3) is strongly associated with fatty liver disease, but the underlying mechanism remains obscure. In this study, we used knock‐in (KI) mice (Pnpla3(148M/M)) to examine the mechanism responsible for accumulat...

Descripción completa

Detalles Bibliográficos
Autores principales: BasuRay, Soumik, Smagris, Eriks, Cohen, Jonathan C., Hobbs, Helen H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605398/
https://www.ncbi.nlm.nih.gov/pubmed/28520213
http://dx.doi.org/10.1002/hep.29273

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605398/
https://www.ncbi.nlm.nih.gov/pubmed/28520213
http://dx.doi.org/10.1002/hep.29273

Ejemplares similares